Seval TÜRKMEN

Seval TÜRKMEN

Almanya Almanya

Biography and Expertise of Seval TÜRKMEN

Work Experience

  • November 2023-April 2025: Deputy Head of National Centre of Genetics, LNS
  • June 2023- present: Head of Hematooncogenetics and Cytogenetics department

National Centre of Genetics, Laboratoire national de santé

  • November 2019-present: Head of the Hematooncogenetics department

National Centre of Genetics, Laboratoire national de santé

  • 2005- September 2019: Head of the cancer genetics department 2010 : Senior Physician (Oberärztin)

Charité Universitätsmedizin Berlin, Institut für medizinische Genetik und Humangenetik Labor Berlin Charité Vivantes Humangenetik

  • 1999- 2005: Clinical and research position and medical residency

Charité Universitätsmedizin Berlin, Institut für Medizinische Genetik Charité Berlin

  • 1997: Fellowship Freie Universität Berlin, Medical Faculty Internship (Dermatology)

Education and Training

2026: Certified longevity physician (Geneva College of Longevity Science)

2017 Certified Yoga teacher (200 hour yoga TTC, Oceanic Yoga School, Goa, India) 2008: German certification as human geneticist

Residency/Fellowship (board certified)

2008

Charité Universitätsmedizin Berlin

Institut für medizinische Genetik und Humangenetik

Dissertation : Molecular analysis of monogenic inherited syndromes

(magna cum laude)(Dr.med)

1991-1997

Dokuz Eylül University Medical Faculty Izmir, Turkey School of Medicine (M.D.)

Clinical Experience

  • Full German approbation as Medical Doctor (MD,2003)
  • German Certification as Human geneticist (Facharzt, September 2008)
  • General genetic counselling (in Turkish, in German and in English)
  • Management of research for rare ataxia, cerebellum hypoplasia and mental retardation syndromes, rare syndromes and hematological neoplasia (molecular genetic analysis, NGS data Analysis with Genetalk, cytogenetics and molecular cytogenetics)
  • Speciality clinic for persons with Sotos syndrome and other overgrowth syndromes with high risk tumor risiko
  • Management of a routine molecular genetic diagnostic service for NSD1 mutations in persons with suspected Sotos syndrome
  • Management of a routine cytogenetics and molecular cytogenetics diagnostic lab for adult and childhood haematological neoplasias
  • Management of cytogenetics and molecular cytogenetics analysis of childhood ALL-Relapsed- Study as a reference Labor
  • Management of cytogenetics and molecular cytogenetics analysis of childhood ALL-Relapsed- Study as a reference Labor

Teaching Experience

Since winter Semester 2021: Bachelor of medicine, Luxemburg University

2002 – September 2019 : Charité Universitätsmedizin Berlin, Institut für medizinische Genetik und Humangenetik

  • Seminar in Human Genetics for medical Students
  • Guidance of four Master`s thesis in Molecular medicine

Guidance of many Bachelor theses

  • Guidance of two degree Dissertation

2014: Anastasia Binder, Immunglobulin light chain aberrations in multiple myeloma

2014-2015: Victoria Münzer, Molecular und molecular cytogenetics Analysis of FOXO1 Gen by CLL-Patients

Language Skills

Turkish (Mother tongue), German (fluent), English (fluent)

Publication List

  1. Schöpflin R, Melo US, Moeinzadeh H, Heller D, Laupert V, Hertzberg J, Holtgrewe M, Alavi N, Klever MK, Jungnitsch J, Comak E, Türkmen S, Horn D, Duffourd Y, Faivre L, Callier P, Sanlaville D, Zuffardi O, Tenconi R, Kurtas NE, Giglio S, Prager B, Latos-Bielenska A, Vogel I, Bugge M, Tommerup N, Spielmann M, Vitobello A, Kalscheuer VM, Vingron M, Mundlos S. Integration of Hi-C with short and long-read genome sequencing reveals the structure of germline rearranged genomes. Nat Commun. 2022 Oct 29;13(1):6470. doi: 10.1038/s41467-022-34053-7.
  2. Jäger K, Mensch J, Grimmig ME, Neuner B, Gorzelniak K, Türkmen S, Demuth I,Hartmann A, Hartmann C, Wittig F, Sporbert A, Hermann A, Fuellen G, Möller S,Walter M. A conserved long-distance telomeric silencing mechanism suppressesmTOR signaling in aging human fibroblasts. Sci Adv. 2022 Aug 19;8(33)
  1. Jouret G, Heide S, Sorlin A, Faivre L, Chantot-Bastaraud S, Beneteau C, Denis-Musquer M, Turnpenny PD, Coutton C, Vieville G, Thevenon J, Larson A, Petit F, Boudry E, Smol T, Delobel B, Duban-Bedu B, Fallerini C, Mari F, Lo Rizzo C, Renieri A, Caberg JH, Denommé-Pichon AS, Tran Mau-Them F, Maystadt I, Courtin T, Keren B, Mouthon L, Charles P, Cuinat S, Isidor B, Theis P, Müller C,

Kulisic M, Türkmen S, Stieber D, Bourgeois D, Scalais E, Klink B. Understanding the new BRD4-related syndrome: Clinical and genomic delineation with an international cohort study. Clin Genet. 2022 Aug;102(2):117-122

  1. Ihlow J, Gross S, Busack L, Flörcken A, Jesse J, Schwarz M, Neuendorff NR, Brünneck AV, Anagnostopoulos I, Türkmen S, Blau IW, Burmeister T, Horst D, Bullinger L, Westermann J. Acute myeloid leukemia: negative prognostic impact of early blast persistence can be in part overcome by a later remission prior to post-induction therapy. Haematologica. 2022 Aug 1;107(8):1773-1785
  2. Elsner J, Mensah MA, Holtgrewe M, Hertzberg J, Bigoni S, Busche A, Coutelier M, de Silva DC, Elçioglu N, Filges I, Gerkes E, Girisha KM, Graul-Neumann L, Jamsheer A, Krawitz P, Kurth I, Markus S, Megarbane A, Reis A, Reuter MS, Svoboda D, Teller C, Tuysuz B, Türkmen S, Wilson M, Woitschach R, Vater I, Caliebe A, Hülsemann W, Horn D, Mundlos S, Spielmann M. Genome sequencing in families with congenital limb malformations. Hum Genet. 2021 Aug;140(8):1229-1239
  1. Elsner J, Mensah MA, Holtgrewe M, Hertzberg J, Bigoni S, Busche A, Coutelier M, de Silva DC, Elçioglu N, Filges I, Gerkes E, Girisha KM, Graul-Neumann L, Jamsheer A, Krawitz P, Kurth I, Markus S, Megarbane A, Reis A, Reuter MS, Svoboda D, Teller C, Tuysuz B, Türkmen S, Wilson M, Woitschach R,

Vater I, Caliebe A, Hülsemann W, Horn D, Mundlos S, Spielmann M. Genome sequencing in families with congenital limb malformations. Hum Genet. 2021 Aug;140(8):1229-1239

Mommaerts K, Bellora C, Lambert P, Türkmen S, Schwamborn JC, Betsou F. Method Optimization of Skin Biopsy-Derived Fibroblast Culture for Reprogramming Into Induced Pluripotent Stem Cells. Biopreserv Biobank. 2021 Aug 18. PMID: 34407379.

  • Ihlow J, Gross S, Neuendorff NR, Busack L, Herneth A, Singh A, Schwarz M, Flörcken A, Anagnostopoulos I, Türkmen S, Burmeister T, Blau IW, Bullinger L, Westermann J. Clinical outcome of older adults with acute myeloid Leukemia: An analysis of a large tertiary referral Center over two decades. J Geriatr Oncol. 2021 May;12(4):540-549
  1. Melo US, Schöpflin R, Acuna-Hidalgo R, Mensah MA, Fischer-Zirnsak B, Holtgrewe M, Klever MK, Türkmen S, Heinrich V, Pluym ID, Matoso E, Bernardo de Sousa S, Louro P, Hülsemann W, Cohen M, Dufke A, Latos-Bieleńska A, Vingron M, Kalscheuer V, Quintero-Rivera F, Spielmann M, Mundlos S. Hi- C Identifies Complex Genomic Rearrangements and TAD-Shuffling in Developmental Diseases.

Am J Hum Genet. 2020 Jun 4;106(6):872-884

  1. Groeneveld-Krentz S, Schroeder MP, Reiter M, Pogodzinski MJ, Pimentel-Gutiérrez HJ, Vagkopoulou R, Hof J, Chen-Santel C, Nebral K, Bradtke J, Türkmen S, Baldus CD, Gattenlöhner S, Haas OA, von Stackelberg A, Karawajew L, Eckert C, Kirschner-Schwabe R. Aneuploidy in children with relapsed B-cell precursor acute lymphoblastic leukaemia: clinical importance of detecting a hypodiploid origin of relapse. Br J Haematol. 2019 Feb 3
  1. Ihlow J, Gross S, Sick A, Schneider T, Flörcken A, Burmeister T, Türkmen S, Arnold R, Dörken B, Westermann J. AML: high serum ferritin at initial diagnosis has a negative impact on long-term survival. Leuk Lymphoma. 2019 Jan;60(1):69-77.
  2. Türkmen S, Spielmann M, Güneş N, Knaus A, Flöttmann R, Mundlos S, Tüysüz B. A Novel de novo FZD2 Mutation in a Patient with Autosomal Dominant Omodysplasia. Mol Syndromol. 2017 Nov;8(6)
  1. Niehr F, Eder T, Pilz T, Konschak R, Treue D, Klauschen F, Bockmayr M, Türkmen S, Jöhrens K, Budach V, Tinhofer I. Multilayered Omics-Based Analysis of a Head and Neck Cancer Model of Cisplatin Resistance Reveals Intratumoral Heterogeneity

and Treatment-Induced Clonal Selection. Clin Cancer Res. 2018 Jan 1;24(1):158-168.

  1. Silva P, Neumann M, Schroeder MP, Vosberg S, Schlee C, Isaakidis K,

Ortiz-Tanchez J, Fransecky LR, Hartung T, Türkmen S, Graf A, Krebs S, Blum H, Müller-Tidow C, Thiede C, Ehninger G, Serve H, Hecht J, Berdel WE, Greif PA, Röllig C, Baldus CD. Acute myeloid leukemia in the elderly is characterized by a distinct genetic and epigenetic landscape. Leukemia. 2017 Jul;31(7):1640-1644.

  1. Bozzetti Cecilia, Türkmen Seval, Richter Ulrich, Fransecky Lars, Gürkan Bal, Carsten-Oliver Schulz, Philipp Hemmati, Arnold Renate, Riess Hanno1 and le Coutre Philipp. A rare case of acute myeloid leukemia with a t(2;3) chromosomal translocation characterized by thrombophilia and chemoresistance J Clin Exp Hematop. 2016;56(1):64-8
  2. Seval Türkmen, Sezgin Sahin,  Naci Koçer, Hartmut Peters, Stefan Mundlos, Beyhan Tüysüz.

Neuroradiological and clinical characterization of Sotos syndrome: Longitudinal observation of six Turkish patients. Genetic Counceling 2015 Vol. 26, No:1 1-12

  1. Schneider T, Flörcken A, Singh A, Türkmen S, Burmeister T, Anagnostopoulos I, Pezzutto A, Dörken B, Westermann J.Flow cytometric maturity score as a novel prognostic parameter in patients with acute myeloid leukemia. Ann Hematol. 2015 May 22.
  2. Neuendorff NR, Schwarz M, Hemmati P, Türkmen S, Bommer C, Burmeister T, Dörken B, le Coutre P, Arnold R, Westermann J. Bcr-abl+ acute myeloid leukemia: Clonal selection of a bcr-abl-negative

subclone as a cause of refractory disease under Nilotinib treatment.Acta Haematol. 2014 Nov 12;133(2):237-241

  1. Türkmen S, Binder A, Gerlach A, Niehage S, Theodora Melissari M, Inandiklioglu N, Dörken B, Burmeister T.: High prevalence of Immunoglobulin Light Chain Gene aberrations as revealed by FISH in Multiple Myeloma and MGUS. Genes Chromosomes Cancer 2014 Aug;53(8):650-6)
  1. Bokemeyer A,, Eckert C, Meyr F, Koerner G, von Stackelberg A, Ullmann R,

Türkmen S, Henze G, Seeger K.: Additional genomic alterations are associated with treatment response and outcome in relapsed childhood ETV6/RUNX1-positive acute lymphoblastic leukemia. Haematologica 2014 Apr;99(4):706-14

  1. AI Riechardt, S Türkmen, AM Joussen: Genetische Diagnostik beim uvealem Melanom. Klinische Monatsblätter für Augenheilkunde 2013 230(S 02)
  1. Lipski AC, Lakotka N, Riechardt AI, Willerding GD, Heufelder J, Türkmen S,

Keilholz U, Moser L, Joussen AM.:Diagnosis of and therapy for choroidal melanoma]. Klin Monbl Augenheilkd. 2013 Oct;230(10)

  1. Türkmen S, Timmermann B, Bartels G, Gröger D, Meyer C, Schwartz S, Haferlach C, Rieder H, Gökbuget N, Hoelzer D, Marschalek R, Burmeister T.: Involvement of the MLL gene in adult T- lymphoblastic leukemia. Genes Chromosomes Cancer. 2012 Dec;51(12):1114-24
  2. Blau O, Baldus CD, Hofmann WK, Thiel G, Nolte F, Burmeister T, Türkmen S, Benlasfer O, Schümann E, Sindram A, Molkentin M, Mundlos S, Keilholz U,Thiel E, Blau IW. Mesenchymal stromal cells of myelodysplastic syndrome and acute myeloid leukemia patients have distinct genetic abnormalities compared with leukemic blasts. Blood 2011 Nov 17;118(20):5583-92.
  1. Türkmen S, Riehn M, Klopocki E, Molkentin M, Reinhardt R, Burmeister T. A BACH2-BCL2L1 fusion gene resulting from a t(6;20)(q15;q11.2) chromosomal

translocation in the lymphoma cell line BLUE-1. Genes Chromosomes Cancer. 2011Jun;50(6):389-96.

  1. Villavicencio-Lorini P, Kuss P, Friedrich J, Haupt J, Farooq M, Türkmen S,

Duboule D, Hecht J, Mundlos S. Homeobox genes d11-d13 and a13 control mouse autopod cortical bone and joint formation. J Clin Invest. 2010 May 10..

  1. Schmidt-Hieber M, Blau IW, Richter G, Türkmen S, Bommer C, Thiel G, Neitzel H,Stroux A, Uharek L, Thiel E, Blau O. Cytogenetic studies in acute leukemia patients relapsing after allogeneic stem cell transplantation. Cancer Genet Cytogenet. 2010 Apr 15;198(2):135-43.
  1. Kaiser M, Lamottke B, Mieth M, Jensen MR, Quadt C, Garcia-Echeverria C, Atadja P, Heider U, von Metzler I, Türkmen S, Sezer O. Synergistic action of the novel HSP90 inhibitor NVP-AUY922 with histone deacetylase inhibitors, melphalan, or doxorubicin in multiple myeloma. Eur J Haematol. 2009 Dec 17.
  2. Kim TD, Türkmen S, Schwarz M, Koca G, Nogai H, Bommer C, Dörken B, Daniel P, le Coutre P. Impact of additional chromosomal aberrations and BCR-ABL kinasedomain mutations on the response to nilotinib in Philadelphia chromosome-positive chronic myeloid leukemia. Haematologica. 2010 Apr;95(4):582-8. Epub 2009 Dec 16.
  1. Türkmen S, Guo G, Garshasbi M, Hoffmann K, Alshalah AJ, Mischung C, Kuss A, Humphrey N, Mundlos S, Robinson PN. CA8 mutations cause a novel syndrome characterized by ataxia and mild mental retardation with predisposition to quadrupedal gait. PLoS Genet. 2009 May;5(5):e1000487. Epub 2009 May 22.

Hucthagowder V, Morava E, Kornak U, Lefeber DJ, Fischer B, Dimopoulou A,

Aldinger A, Choi J, Davis EC, Abuelo DN, Adamowicz M, Al-Aama J, Basel-Vanagaite L, Fernandez B, Greally MT, Gillessen-Kaesbach G, Kayserili H, Lemyre E, Tekin M, Türkmen S, Tuysuz B, Yüksel-Konuk B, Mundlos S, Van Maldergem L, Wevers RA, Urban Z. Loss-of-function mutations in ATP6V0A2 impair vesicular trafficking, tropoelastin secretion and cell survival. Hum Mol Genet. 2009 Jun 15;18(12):2149- 65.

  1. Tuysuz B, Mizumoto S, Sugahara K, Celebi A, Mundlos S, Turkmen S. Omani-type spondyloepiphyseal dysplasia with cardiac involvement caused by a missense mutation in CHST3. Clin Genet. 2009 Apr;75(4):375-83.
  1. Tüysüz B, Gazioğlu N, Ungür S, Aji DY, Türkmen S. The time of onset of abnormal calcification in spondylometaepiphyseal dysplasia, short limb-abnormal calcification type. Pediatr Radiol. 2009 Jan;39(1):84-9.
  2. Humphrey N, Mundlos S, Türkmen S. Genes and quadrupedal locomotion in humans. Proc Natl Acad Sci U S A. 2008 May 27;105(21):E26.
  1. Türkmen S, Hoffmann K, Demirhan O, Aruoba D, Humphrey N, Mundlos S. Cerebellar hypoplasia, with quadrupedal locomotion, caused by mutations in the very low-density lipoprotein receptor gene. Eur J Hum Genet. 2008 Sep;16(9):1070-4.
  2. Tüzel E, Samli H, Kuru I, Türkmen S, Demir Y, Maralcan G, Güler C. Association of hypospadias with hypoplastic synpolydactyly and role of HOXD13 gene mutations. Urology. 2007 Jul;70(1):161-4.
  1. Stevenson D.A., Turkmen S, Pysher T.J., Ward R.M., Carey J.C.:

Genetic basis of pulmonary lymphangiectasia. Helix Review Series; 2007 Volume 4, Issue 1, pp 10-13)

  1. Meyer S, Fergusson WD, Whetton AD, Moreira-Leite F, Pepper SD, Miller C, Saunders EK, White DJ, Will AM, Eden T, Ikeda H, Ullmann R, Tuerkmen S, Gerlach A, Klopocki E, Tönnies H. Amplification and translocation of 3q26 with overexpression of EVI1 in Fanconi anemia-derived childhood acute myeloid leukemia with biallelic FANCD1/BRCA2 disruption.Genes Chromosomes Cancer. 2007 Apr;46(4):359-72.
  1. Jakob C, Egerer K, Liebisch P, Türkmen S, Zavrski I, Kuckelkorn U, Heider U, Kaiser M, Fleissner C, Sterz J, Kleeberg L, Feist E, Burmester GR, Kloetzel PM,

Sezer O. Circulating proteasome levels are an independent prognostic factor for survival in multiple myeloma. Blood. 2007 Mar 1;109(5):2100-5.

  1. Kuru I, Maralcan G, Yucel A, Aktepe F, Turkmen S, Solak M. Synpolydactyly of the foot in homozygotes. J Am Podiatr Med Assoc. 2006 Jul-Aug;96(4):297-304.
  1. Türkmen S, Demirhan O, Hoffmann K, Diers A, Zimmer C, Sperling K, Mundlos S. Cerebellar hypoplasia and quadrupedal locomotion in humans as a recessive trait mapping to chromosome 17p. J Med Genet. 2006 May;43(5):461-4.
  1. Tufan F, Cefle K, Türkmen S, Türkmen A, Zorba U, Dursun M, Oztürk S, Palandüz S, Ecder T, Mundlos S, Horn D. Clinical and molecular characterization of two adults with autosomal recessive Robinow syndrome. Am J Med Genet A. 2005 Jul 15;136(2):185-9.
  2. Tatton-Brown K, Douglas J, Coleman K, Baujat G, Cole TR, Das S, Horn D, Hughes HE, Temple IK, Faravelli F, Waggoner D, Turkmen S, Cormier-Daire V, Irrthum A, Rahman N; Childhood Overgrowth Collaboration. Genotype-phenotype

associations in Sotos syndrome: an analysis of 266 individuals with NSD1 aberrations. Am J Hum Genet. 2005 Aug;77(2):193-204.

  1. Demirhan O*, Türkmen S*, Schwabe GC, Soyupak S, Akgül E, Tastemir D, Karahan D, Mundlos S, Lehmann K. A homozygous BMPR1B mutation causes a new subtype of acromesomelic chondrodysplasia with genital anomalies. J Med Genet. 2005 Apr;42(4):314-7.

*equal contrubution

  1. Kuru I, Samli H, Yucel A, Bozan ME, Turkmen S, Solak M. Hypoplastic

synpolydactyly as a new clinical subgroup of synpolydactyly. J Hand Surg Br. 2004 Dec;29(6):614-20.

  1. Schwabe GC, Türkmen S, Leschik G, Palanduz S, Stöver B, Goecke TO, Mundlos S. Brachydactyly type C caused by a homozygous missense mutation in the prodomain of CDMP1. Am J Med Genet A. 2004 Feb 1;124A(4):356-63.
  2. Türkmen S, Gillessen-Kaesbach G, Meinecke P, Albrecht B, Neumann LM, Hesse V, Palanduz S, Balg S, Majewski F, Fuchs S, Zschieschang P, Greiwe M, Mennicke K, Kreuz FR, Dehmel HJ, Rodeck B, Kunze J, Tinschert S, Mundlos S, Horn D. Mutations in NSD1 are responsible for Sotos syndrome, but are not a frequent finding in other overgrowth phenotypes. Eur J Hum Genet. 2003 Nov;11(11):858-65.
  1. Katzke S, Booms P, Tiecke F, Palz M, Pletschacher A, Türkmen S, Neumann LM, Pregla R, Leitner C, Schramm C, Lorenz P, Hagemeier C, Fuchs J, Skovby F,

Rosenberg T, Robinson PN. TGGE screening of the entire FBN1 coding sequence in 126 individuals with marfan syndrome and related fibrillinopathies. Hum Mutat. 2002 Sep;20(3):197-208.

Oral presentations (selected ones)

  1. Seval Türkmen, Mike Urban, Katarina Lehmann, Christiane Bommer, Hannelore Körner, Gundula Thiel.:

A de novo apparently balanced complex chromosomal rearrangement (CCR) involving chromosomes 2,5,11,16,18 in a woman with mental retardation detected by M-FISH (Multi-color FISH) and YACs (2001, 12th ESC Congress)

  1. Seval Türkmen: Molekulargenetische Analyse des Sotos-Syndroms (2001, für 7. Familientreffen der Eltern-Initiative Sotos Syndrom)
  1. Türkmen S, Gillessen-Kaesbach G, Meinecke P, Albrecht B, Neumann LM, Hesse V, Palanduz S, Balg S, Majewski F, Fuchs S, Zschieschang P, Greiwe M, Mennicke K, Kreuz FR, Dehmel HJ, Rodeck B, Kunze J, Tinschert S, Mundlos S, Horn D. :

Mutationsin NSD1 are responsible for Sotos syndrome, but are not a frequent finding in other overgrowth phenotypes

(2003, 14. Jahrestagung der Deutschen Gesellschaft für Humangenetik)

  1. Türkmen S*, Demirhan O*, Schwabe GC, Soyupak S, Akgül E, Tastemir D, Karahan D,Mundlos S, Lehmann K. A.:

Homozygous BMPR1B mutation causes a new subtype of acromesomelic chondrodysplasia with genital anomalies

(2004, European Society of Human Genetics Conference)

  1. Türkmen S, Demirhan O, Hoffmann K, Diers A, Zimmer C, Sperling K, Mundlos S. Cerebellar hypoplasia and quadrupedal locomotion in humans as a recessive trait mapping to chromosome 17p. (2006, 17. Jahrestagung der Deutschen Gesellschaft für Humangenetik)

Türkmen S: Genetische Aspekte der verwandten Ehe (2006 für Rathaus Neukölln, Jugendamt Neukölln)

  1. Türkmen S, Guo G, Garshasbi M, Hoffmann K, Alshalah AJ, Mischung C, Kuss A, Humphrey N, Mundlos S, Robinson PN.:

CA8 mutations cause a novel syndrome characterized by ataxia and mild mental retardation with predisposition to quadrupedal gait.

(2009, 20. Jahrestagung der Deutschen Gesellschaft für Humangenetik und European Society of Human Genetics Conference)

  1. Türkmen S:

Genes and Overgrowth Syndromes

(2009, Turkish Endocrinology Conference)

  1. Türkmen S:

Genes and quadrupedal locomotion

(2010, 1.International Human Genetics conference, Egypt)

  1. Türkmen S, Riehn M, Klopocki E, Molkentin M, Reinhardt R, Burmeister T. A.; BACH2-BCL2L1 fusion gene resulting from a t(6;20)(q15;q11.2) chromosomal translocation in the lymphoma cell line BLUE-1

(2012,Tumorzytogenetische Arbeitstagung)

  1. Türkmen S.:

Klinische Relevanz von Chromosomenaberrationen bei Lymphatische Neoplasien, (2012, Zytogenetische Arbeitstagung)

  1. Türkmen S.:

Genetische Aspekte der familiäre Disposition

(2013, für Fachverband Evangelische Jugendhilfen e.V.

  1. Türkmen S.:

The impacts of Cytogenetics and Molecular Cytogenetics analysis in childhood leukemia (2013, Turkish Pediatric Genetics Conference)

  1. Türkmen S, Binder A, Gerlach A, Niehage S, Theodora Melissari M, Inandiklioglu N, Dörken B, Burmeister T.:

High prevalence of Immunoglobulin Light Chain Gene aberrations as revealed by FISH in Multiple Myeloma and MGUS

(2014, Tumorgenetische Arbeitstagung)

  1. Türkmen S

Genetics of Multiple Myeloma

(2016, Hematology and Genetics Conference)

Türkmen S

Genetics of the pediatric hematological neoplasia (2018, Education session) Turkish pediatric conference)

  1. Türkmen S

Why is the genetics analysis important for the MM patients (2020, turkish genetic society, online session)

  1. Türkmen S

The genetics analysis of pediatric leukemia and their impact on the therapy (2021, Istanbul University genetic Department training , online session)

Abstracts (selected ones)

  1. Seval Türkmen, Christiane Bommer, Stephan Rachwitz, Nick Robinson, Stefan Mundlos: Cytogenetic and Molecular Cytogenetic analysis of a 10;11 rearrangement in adult acute leukaemia (2004, Medizinisiche Genetik Heft)
  1. Seval Türkmen, Silké Michaelis , Ali Fuat Okuducu, Nanette Sarioglu, Stefan Mundlos.: Familial congenital non-immune hydrops, chylothorax, and pulmonary lymphangiectasia. (2007, Medizinische Genetik Heft)
  2. Smithson SF, Bargal R2, Cormier-Daire V, Le Merrer M, Hall CM, Tüysüz B, Türkmen S, Raas-

Rothschild A:

Spondylo-meta-epiphyseal dysplasia short limb-abnormal calcification results from mutations in the DDR2 gene

(Clinical Genetics Society in London)

  1. Jaspal S Kaeda, Ken Mills, Michael Kharas, Michaela Schwartz, Christian Oberender, Beppe Saglio, Bärbel Pawlaczyk, Antje Van Lessen, Seval Türkmen, Claudia Baldus, Frauke Ringel, Thomas Pretzsch, Anna Serra, Anne Carson, Mary-Frances McMullin, Jörg Westermann, Peter Daniel, Bernd Dörken, le Coutre Philipp. Increased MSI2 expression is associated with aggressive CML and AML (American Society of Hematology,2011)
  2. Seval Türkmen , Peter Krawitz, Magdalena Brachaczek, Hanan Afifi, Maha Zaki:Phenotype and genotype variability of the PMM2 gene mutation among the same Egyptian family

(ESHG, 2011)

  1. Jaspal S Kaeda , Christian Oberender, Concetta Quintarelli, Nicola Esposita, Daniel Neuman, Philipp Hematti, Regina Schleede, Ken Mills, Anna Serra, Michaela Schwarz, Seval Türkmen, Frauke Ringel, Thomas Pretzsch, Renate Arnold, Bernd Dörken, Pane Fabrizio and Philipp le Coutre.:

Differential expression of SHP-1 levels in chronic, advanced phase CML and AML patients (American Society of Hematology,2012)

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